2D6 Feet in a Random Direction is one of my favorite gaming podcasts. It delivers gaming news from well-connected and knowledgeable hosts [Chris Hanrahan and Brian Isikoff] and guests, reviews, actual play reports, and California and USA west-coast gaming scene news.
The show's producers recently had some issues with their web hosting, and so I offered to and have taken over hosting the site—leaving Chris and Brian free to work on the show itself.
If you're a gamer, the perspectives from the 2D6 cast are well-worth listening to. If you're regularly buying and trying new games, I'd classify it as a must-listen!